Expression of hypoxia-inducible factor 1alpha in human normal, benign, and malignant prostate tissue.


OBJECTIVE To investigate hypoxia-inducible factor 1alpha (HIF-1alpha) protein expression in normal prostates (NP), benign prostatic glandular hyperplasia (BPH), and prostate adenocarcinoma (Pca). METHODS HIF-1alpha protein expression was determined by immunohistochemistry in formalin-fixed and paraffin-embedded specimens obtained from 13 cases of NP, 28… (More)


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