Expression of hypothalamic-pituitary-thyroid axis related genes in the human skin.

  title={Expression of hypothalamic-pituitary-thyroid axis related genes in the human skin.},
  author={Andrzej T Slominski and Jacobo Wortsman and Leonard D. Kohn and Kenneth B. Ain and Gopalakrishnan M. Venkataraman and Alexander Pisarchik and Jonathan H Chung and Cesidio Giuliani and Mark Thornton and George Slugocki and Desmond J. Tobin},
  journal={The Journal of investigative dermatology},
  volume={119 6},
The skin is commonly affected in thyroid diseases, but the mechanism for this association is still unclear. As the skin expresses numerous neuroendocrine elements, we tested the additional cutaneous expression of mediators operating in the hypothalamic-pituitary-thyroid axis. We found significant expression of the thyroid-stimulating hormone receptor mRNA in cultured keratinocytes, epidermal melanocytes, and melanoma cells. The presence of thyroid-stimulating hormone receptor was confirmed by… CONTINUE READING


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