Expression of hurpin, a serine proteinase inhibitor, in normal and pathological skin: overexpression and redistribution in psoriasis and cutaneous carcinomas

@article{Moussali2005ExpressionOH,
  title={Expression of hurpin, a serine proteinase inhibitor, in normal and pathological skin: overexpression and redistribution in psoriasis and cutaneous carcinomas},
  author={Hayat Moussali and Matilda Bylaitė and Thomas Welss and Harry F. Abts and Thomas Ruzicka and Markus Walz},
  journal={Experimental Dermatology},
  year={2005},
  volume={14}
}
Abstract:  Hurpin was identified by differential display analysis studying UV‐repressible genes in the keratinocyte cell line HaCaT. We have previously reported that hurpin mRNA is overexpressed in psoriatic skin compared to non‐lesional or normal skin; hurpin inhibits cathepsin L and that, after overexpression in keratinocytes, hurpin decreases UV‐induced apoptosis. To further study the expression of hurpin, we have isolated monoclonal antibodies against hurpin and analyzed its expression in… Expand
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References

SHOWING 1-10 OF 48 REFERENCES
Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples
TLDR
The results are consistent with a role for this protease in the terminal differentiation of keratinocytes in patients with cutaneous diseases. Expand
Aberrant expression of apoptosis-related molecules in psoriatic epidermis.
TLDR
Results indicate that psoriatic epidermis shows aberrant expression of apoptosis-related molecules representing suppressed apoptotic process, which might be related to characteristic histopathology. Expand
Immunohistochemical Localization of Cathepsin L and Cystatin A in Normal Skin and Skin Tumors
TLDR
The results suggest that the immunohistochemical analysis of cathepsin L and cystatin A is a useful indicator for an aspect of malignancy in human epidermal keratinocytes. Expand
Overexpression of serpin squamous cell carcinoma antigens in psoriatic skin.
TLDR
The results suggest that overexpression of squamous cell carcinoma antigens is associated with the disease activity of psoriasis. Expand
Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis.
TLDR
It is demonstrated that hurpin is a potent and selective inhibitor of the archetypal lysosomal cysteine proteinase cathepsin L (catL) and proposed that a physiological role of hurpins is to protect epithelial cells from ectopic catL. Expand
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling
  • W. Roth, J. Deussing, +10 authors C. Peters
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2000
TLDR
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling is shown to be essential for epidermal homeostasis and regular hair follicles morphogenesis and cycling. Expand
Expression of cathepsin L in human tumors.
TLDR
Results of the present study suggest that cancers in general express higher levels of cathepsin L than do normal tissues and may prove useful as a diagnostic or prognostic marker of human malignancy. Expand
Invasion of melanoma cells into dermal connective tissue in vitro: Evidence for an important role of cysteine proteases
TLDR
An improved culture model that allows the detailed study of melanoma cell invasion in vitro and indicates an important role of cysteine proteases for tumor invasion is indicated. Expand
SCCA2-like serpins mediate genetic predisposition to skin tumors.
TLDR
Immunohistochemical analysis of samples from two independent series of Italian and Korean patients with squamous cell carcinoma of the skin indicated a significant association between SCCA2 protein expression and younger age at tumor onset, providing evidence that S CCA2-like serpins mediate genetic predisposition to skin cancer in a mouse model and in humans. Expand
The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma.
TLDR
Human cathepsin K is a novel cysteine protease previously reported to be restricted in its expression to osteoclasts that may contribute to the invasive potential of breast cancer cells, including those that metastasize to bone. Expand
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4
5
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