Expression of human transforming growth factor alpha by Chinese hamster ovarian tumors in nude mice causes hypercalcemia and increased osteoclastic bone resorption.

@article{Yates1992ExpressionOH,
  title={Expression of human transforming growth factor alpha by Chinese hamster ovarian tumors in nude mice causes hypercalcemia and increased osteoclastic bone resorption.},
  author={Allen J. Yates and Brendan F. Boyce and G Favarato and T. B. Aufdemorte and Claudio Marcelli and Mary Beth Kester and Russell Walker and B C Langton and Lynda F. Bonewald and Gregory R. Mundy},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1992},
  volume={7 7},
  pages={847-53}
}
Transforming growth factor alpha (TGF-alpha) is a polypeptide regulator of cell growth produced by many malignant tumors. It stimulates osteoclastic resorption in bone organ culture and osteoclast-like cell formation in marrow culture. To determine whether tumor production of TGF-alpha can cause hypercalcemia in vivo, we used Chinese hamster ovarian (CHO… CONTINUE READING