Expression of human telomerase reverse transcriptase mediates the senescence of mesenchymal stem cells through the PI3K/AKT signaling pathway.

@article{Zhao2015ExpressionOH,
  title={Expression of human telomerase reverse transcriptase mediates the senescence of mesenchymal stem cells through the PI3K/AKT signaling pathway.},
  author={Qiang Zhao and Xue-yao Wang and Xiao-Xia Yu and Ying-Xian Zhai and Xu He and Shan Wu and Ying-ai Shi},
  journal={International journal of molecular medicine},
  year={2015},
  volume={36 3},
  pages={
          857-64
        }
}
Multipotent mesenchymal stem cells (MSCs) are widely used as seed cells in studies of tissue engineering and regenerative medicine; however, their clinical application is limited due to replicative senescence. It has been demonstrated that telomerase expression extends the lifespan and maintains the bone-forming ability of MSCs; however, the detailed role and the underlying molecular mechanisms in MSCs remain largely unknown. In the present study, we found that senescence was associated with… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Knockdown of hTERT by siRNA inhibits cervical cancer cell growth in vitro and in vivo.

  • International journal of oncology
  • 2014
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Inducible immortality in hTERT-human mesenchymal stem cells.

  • Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 2012
VIEW 2 EXCERPTS

Similar Papers

Loading similar papers…