Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and atherosclerotic lesions.

@article{Hirano1999ExpressionOH,
  title={Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and atherosclerotic lesions.},
  author={Ken-ichi Hirano and Seiji Yamashita and Yoshihiro Nakagawa and Takeshi Ohya and Fumihiko Matsuura and Kyoko Tsukamoto and Yoshihisa Okamoto and Akifumi Matsuyama and Kazuya Matsumoto and Jun‐ichiro Miyagawa and Yuji Matsuzawa},
  journal={Circulation research},
  year={1999},
  volume={85 1},
  pages={108-16}
}
The scavenger receptor class B type I (SR-BI) and its human homologue CLA-1 (CD36 and LIMPII Analogous-1) have recently been identified to bind HDL and mediate the selective uptake of HDL lipids. Tissue distribution of both murine and human receptors is quite similar, in that they are expressed abundantly in liver and steroidogenic tissues. However, expression and function of the human SR-BI (hSR-BI), in the periphery of reverse cholesterol transport such as macrophages, are still unclear. In… CONTINUE READING