Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C.

@article{Kummer1996ExpressionOH,
  title={Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C.},
  author={Jean Alain Kummer and Arthur W. M. van der Kamp and Franca Citarella and Anton J. G. Horrevoets and C. Erik Hack},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 16},
  pages={9281-6}
}
Human granzyme A is one of the serine proteinases present in the granules of cytotoxic T lymphocytes and natural killer cells. Granzymes are synthesized as inactive proenzymes with an amino-terminal prodipeptide, which is processed during transport of granzymes to the cytotoxic granules, where they are stored as active proteinases. In this study, we… CONTINUE READING