Expression of human gonadotropin-releasing hormone receptor gene in the placenta and its functional relationship to human chorionic gonadotropin secretion.

@article{Lin1995ExpressionOH,
  title={Expression of human gonadotropin-releasing hormone receptor gene in the placenta and its functional relationship to human chorionic gonadotropin secretion.},
  author={Linus S Lin and Veronica J. Roberts and Samuel Yen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1995},
  volume={80 2},
  pages={580-5}
}
Placental GnRH is one of the potential paracrine regulators of hCG secretion from the trophoblasts during pregnancy. Maternal serum hCG levels exhibit an exponential rise during the first 6 weeks of pregnancy, peak at 9-10 weeks, decline to a nadir at 20 weeks, and remain at low levels during the rest of pregnancy. However, the placental content of GnRH does not parallel the time course of hCG secretion, and GnRH messenger ribonucleic acid (mRNA) levels in the placenta remain unchanged during… CONTINUE READING

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However , the placental content of GnRH does not parallel the time course of hCG secretion , and GnRH messenger ribonucleic acid ( mRNA ) levels in the placenta remain unchanged during pregnancy .
The relative responsiveness of hCG secretion to GnRH stimulation at 10(-7 ) mol / L was further evaluated in placental explants at 6 , 9 , and 40 weeks gestation .
Placental GnRH is one of the potential paracrine regulators of hCG secretion from the trophoblasts during pregnancy .
These data provide a mechanistic understanding that the paracrine / autocrine regulation of hCG secretion by placental GnRH is mediated through an increase followed by a decline in GnRH receptor gene expression from the first trimester to term placenta .
Placental GnRH is one of the potential paracrine regulators of hCG secretion from the trophoblasts during pregnancy .
The present study demonstrates , for the first time , that GnRH receptor mRNA is expressed in both cytotrophoblasts and syncytiotrophoblasts and exhibits changes paralleling the time course of hCG secretion during pregnancy .
The present study demonstrates , for the first time , that GnRH receptor mRNA is expressed in both cytotrophoblasts and syncytiotrophoblasts and exhibits changes paralleling the time course of hCG secretion during pregnancy .
These data provide a mechanistic understanding that the paracrine / autocrine regulation of hCG secretion by placental GnRH is mediated through an increase followed by a decline in GnRH receptor gene expression from the first trimester to term placenta .
These data provide a mechanistic understanding that the paracrine / autocrine regulation of hCG secretion by placental GnRH is mediated through an increase followed by a decline in GnRH receptor gene expression from the first trimester to term placenta .
These data provide a mechanistic understanding that the paracrine / autocrine regulation of hCG secretion by placental GnRH is mediated through an increase followed by a decline in GnRH receptor gene expression from the first trimester to term placenta .
The relative responsiveness of hCG secretion to GnRH stimulation at 10(-7 ) mol / L was further evaluated in placental explants at 6 , 9 , and 40 weeks gestation .
However , the placental content of GnRH does not parallel the time course of hCG secretion , and GnRH messenger ribonucleic acid ( mRNA ) levels in the placenta remain unchanged during pregnancy .
Placental GnRH is one of the potential paracrine regulators of hCG secretion from the trophoblasts during pregnancy .
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