Expression of human glucocorticoid receptor in lymphocytes of patients with autoimmune hepatitis.

@article{Rai2004ExpressionOH,
  title={Expression of human glucocorticoid receptor in lymphocytes of patients with autoimmune hepatitis.},
  author={Tsuyoshi Rai and Hiromasa Ohira and Jun Tojo and Kazumichi Abe and Junko Yokokawa and Junko Takiguchi and Shoichiro Shishido and Yukio Sato},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2004},
  volume={29 3},
  pages={148-152}
}
Background and aim: Alternative splicing of human glucocorticoid receptor (hGR) premessenger RNA (mRNA) generates two highly homogenous isoforms, termed hGRalpha and hGRbeta. hGRalpha is a ligand-activated transcription factor, which, in the hormone-bound state, modulates the expression of glucocorticoid-responsive genes by binding to specific glucocorticoid response element DNA sequences. In contrast, hGRbeta may be an endogenous inhibitor of glucocorticoid action and transcriptionally… CONTINUE READING
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