Expression of human glucocerebrosidase in long-term reconstituted mice following retroviral-mediated gene transfer into hematopoietic stem cells.

@article{Correll1990ExpressionOH,
  title={Expression of human glucocerebrosidase in long-term reconstituted mice following retroviral-mediated gene transfer into hematopoietic stem cells.},
  author={Pamela H. Correll and Yvonne Kew and Louise Perry and Roscoe O. Brady and John K. Fink and Stefan Karlsson},
  journal={Human gene therapy},
  year={1990},
  volume={1 3},
  pages={277-87}
}
A retroviral vector (GTN) in which the glucocerebrosidase (GCase) cDNA is driven by the Moloney murine leukemia virus (Mo-MuLV) long terminal repeat (LTR) was tested for transfer efficiency and expression of the GCase gene in long-term reconstituted mice. Eleven W/Wv mice were transplanted with unselected GTN-infected bone marrow cells and 10 of these mice… CONTINUE READING