Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells.

@article{Lau1999ExpressionOH,
  title={Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells.},
  author={K M Lau and S. C. Mok and S. M. Ho},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 10},
  pages={5722-7}
}
Our understanding of the roles played by sex hormones in ovarian carcinogenesis has been limited by a lack of data concerning the mode of sex hormone action in human ovarian surface epithelial (HOSE) cells, the tissue of origin of >90% of ovarian cancers. We have compared the relative abundance of estrogen receptor (ER)alpha, ERbeta, progesterone receptor (PR), and androgen receptor (AR) mRNA in four primary cultures of HOSE cells obtained from postmenopausal women to those found in late serous… CONTINUE READING
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  • M. I. Edelson, C. C. Lau, +6 authors 197–202. Medical Sciences
  • Proc. Natl. Acad. Sci. USA 96
  • 1999

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