Expression of human cytochrome P4501A1 (CYP1A1) in Saccharomyces cerevisiae inhibits cell division.

@article{Beresford1996ExpressionOH,
  title={Expression of human cytochrome P4501A1 (CYP1A1) in Saccharomyces cerevisiae inhibits cell division.},
  author={Alan P Beresford and Rodney J. Taylor and J A Ashcroft and John Ayrton and Geoffrey T. Tucker and S Wynne Ellis},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1996},
  volume={26 10},
  pages={1013-23}
}
1. Saccharomyces cerevisiae cells, genetically engineered to express human cytochrome P4501A1 (CYP1A1), have a mean doubling time of 5.8 h, which is considerably slower than that of control yeast cells that have undergone the same transformation process but with a plasmid lacking CYP1A1 cDNA (3.3 h). 2. A smaller reduction in the rate of cell division is… CONTINUE READING