Expression of human apolipoprotein B100 in transgenic mice. Editing of human apolipoprotein B100 mRNA.

@article{Chiesa1993ExpressionOH,
  title={Expression of human apolipoprotein B100 in transgenic mice. Editing of human apolipoprotein B100 mRNA.},
  author={Giulia Chiesa and Dianne Johnson and Zemin Yao and Thomas L. Innerarity and Robert W. Mahley and Stephen G. Young and Rudolf Hammer and Helen H. Hobbs},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 32},
  pages={23747-50}
}
Apolipoprotein B (apoB) is a large glycoprotein that circulates in plasma as a major constituent of numerous lipoproteins. ApoB exists in two forms: apoB48 and apoB100. ApoB48 is identical in sequence to the N-terminal region of apoB100 and is generated by sequence-specific mRNA editing of the apoB100 transcript. Here, we describe the development of a line of mice expressing a human apoB transgene driven by promoter/enhancer sequences from the transthyretin gene. In these mice, immunodetectable… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…