Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia.

@article{EscolGil2000ExpressionOH,
  title={Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia.},
  author={Joan Carles Escol{\`a}-Gil and Josep Julve and A Marzal-Casacuberta and Jordi Ord{\'o}{\~n}ez-Llanos and Francesc Gonz{\'a}lez-Sastre and Francisco Blanco-Vaca},
  journal={Journal of lipid research},
  year={2000},
  volume={41 8},
  pages={1328-38}
}
Familial combined hyperlipidemia (FCHL) is a common inherited hyperlipidemia and a major risk factor for atherothrombotic cardiovascular disease. The cause(s) leading to FCHL are largely unknown, but the existence of unidentified "major" genes that would increase VLDL production and of "modifier" genes that would influence the phenotype of the disease has been proposed. Expression of apolipoprotein A-II (apoA-II), a high density lipoprotein (HDL) of unknown function, in transgenic mice produced… CONTINUE READING