Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations.

@article{Santos2009ExpressionOH,
  title={Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations.},
  author={Susana Ferrao Santos and Nathalie Pierrot and Nicole Morel and Philippe Gailly and Christian Jean-Marie Sindic and J. N. Octave},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 15},
  pages={4708-18}
}
Synchronous calcium oscillations are observed in primary cultures of rat cortical neurons when mature networks are formed. This spontaneous neuronal activity needs an accurate control of calcium homeostasis. Alteration of intraneuronal calcium concentration is described in many neurodegenerative disorders, including Alzheimer disease (AD). Although processing of amyloid precursor protein (APP) that generates Abeta peptide has critical implications for AD pathogenesis, the neuronal function of… CONTINUE READING

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