Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes.

@article{Kay1992ExpressionOH,
  title={Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes.},
  author={Mark A. Kay and Patricia A Baley and Steve S Rothenberg and Frances E. Leland and Louise J Fleming and Katherine Parker Ponder and Tao Liu and Milton L Finegold and Gretchen D Darlington and William J. Pokorny},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 1},
  pages={89-93}
}
The liver represents an excellent organ for gene therapy since many genetic disorders result from the deficiency of liver-specific gene products. We have previously demonstrated that transgenic mouse hepatocytes can be heterologously transplanted into congenic recipients where they survived indefinitely and continued to function as hepatocytes. Here we demonstrate the autologous transplantation of retrovirally transduced canine hepatocytes. At least 1 x 10(9) hepatocytes or 5% of the liver mass… CONTINUE READING

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