Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice.

@article{Dente1988ExpressionOH,
  title={Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice.},
  author={Luciana Dente and Ulrich U R{\"u}ther and Marco Tripodi and Erwin F Wagner and R. Cortese},
  journal={Genes & development},
  year={1988},
  volume={2 2},
  pages={
          259-66
        }
}
The human genome contains three alpha 1-glycoprotein genes (AGP-A, AGP-B, and AGP-B') encoding for slightly different forms of the protein. The major component of human alpha 1-acid glycoprotein found in plasma is coded by AGP-A, which is expressed in liver and in hepatoma cell lines and is induced by inflammatory stimuli. We have studied the regulation of the cloned AGP-A gene by transfection into cell lines of hepatic and nonhepatic origin. Unlike any other liver-specific gene investigated so… CONTINUE READING
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