Expression of human HPRT in the central nervous system of transgenic mice

Severe deficiency of hypoxanthine phosphoribosyltransferase (HPRT) in man results in the Lesch–Nyhan syndrome, an X-linked neurological disorder characterized by mental retardation, choreoathetosis and a compulsive tendency towards self-mutilation1. Although the HPRT gene is normally constitutively expressed in all tissues at low levels, expression is… CONTINUE READING