Expression of human GFRα-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves

@article{Hase1999ExpressionOH,
  title={Expression of human GFR$\alpha$-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves},
  author={Asako Hase and Hidenori Suzuki and Kiichi Arahata and Chihiro Akazawa},
  journal={Neuroscience Letters},
  year={1999},
  volume={269},
  pages={55-57}
}
Characterization of glial cell line‐derived neurotrophic factor family receptor α‐1 in peripheral nerve Schwann cells
TLDR
The expression of GFRα‐1 in bovine peripheral nerve in vivo was characterized and immunoreactivity was localized adjacent to the outermost layer of myelin sheath, as well as in the endoneurium and axoplasm.
GDNF FAMILY RECEPTORS IN PERIPHERAL TARGET INNERVATION AND HORMONE PRODUCTION
TLDR
This work has shown that the GDNF family factors act as a “spatially aggregating force” in the development of parasympathetic and enteric neurons and PSPN may protect the brain from ischaemia and RET mutations in human diseases.
Age‐associated decrease in GDNF and its cognate receptor GFRα‐1 protein expression in human skin
TLDR
There is a decrease in epidermal GDNF and GFRα‐1 protein expression in normal human skin with ageing, and the consequences of this is that GFR α‐1‐mediated signalling is altered during the ageing process.
Expression of trophic factors receptors during reinnervation after recurrent laryngeal nerve injury
TLDR
The aim of this work was to determine the timing of the production of Netrin‐1 and GDNF receptors during RLN regeneration and correlate this with the previously identified timing of up‐regulation of their trophic factors in the laryngeal muscles.
Glial cell line-derived neurotrophic factor (GDNF) protein content in rat skeletal muscle is altered by increased physical activity in vivo and in vitro
TLDR
The results suggest that GDNF protein content in skeletal muscle may be controlled by stretch, where it may increase GDNFprotein content, and membrane depolarization/ACh which acts to decrease GDNF Protein content.
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TLDR
It is shown that GDNF binds to, and induces tyrosine phosphorylation of, the product of the c-ret proto-oncogene, an orphan receptor tyrosin kinase, in a GDNF responsive motor-neuron cell line, which encodes a functional receptor for GDNF that may mediate its neurotrophic effects on motor and dopaminergic neurons.
Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons
TLDR
The findings indicate GDNF is a new neurotrophic factor for developing peripheral neurons and suggest possible non-neuronal roles for GDNF in the developing reproductive system.
Characterization of a multicomponent receptor for GDNF
TLDR
It is demonstrated that physiological responses to GDNF require the presence of a novel glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-α) that is expressed on GDNF-responsive cells and binds GDNF with a high affinity, which supports the hypothesis that GDNF uses a multi-subunit receptor system in which GDN FR-α and Ret function as the ligand-binding and signalling components.
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TLDR
Glial cell line-derived neurotrophic factor (GDNF), originally identified as a trophic factor specific for dopaminergic neurons, was found to be 75-fold more potent than the neurotrophins in supporting the survival of purified embryonic rat motoneurons in culture and to be a good candidate for treatment of motoneuron disease.
In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons
TLDR
It is found that GDNF is retrogradely transported, in a receptor-mediated fashion, by spinal cord motor neurons in neonatal rats, and is the most potent motor neuron trophic factor found so far.
Prominent expression of glial cell line–derived neurotrophic factor in human skeletal muscle
TLDR
Results suggest that GDNF is produced by skeletal muscle and taken up at the nerve terminals for retrograde transport by axons, thus, GDNF in human skeletal muscle may be involved in promoting motor neuron survival as a target‐derived neurotrophic factor.
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TLDR
It is shown that glial-cell-line-derived neurotrophic factor (GDNF)7, a distant member of the transforming growth factor(TGF)-β superfamily, signals through the Ret RTK, and that GDNF, in addition to its potential role in the differentiation and survival of central nervous system neurons8–12, has profound effects on kidney organogenesis and the development of the peripheral nervous system.
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