Expression of human FUS protein in Drosophila leads to progressive neurodegeneration

@article{Chen2011ExpressionOH,
  title={Expression of human FUS protein in Drosophila leads to progressive neurodegeneration},
  author={Yanbo Chen and Mengxue Yang and Jianwen Deng and Xiaoping Chen and Ye Ye and Li Zhu and Jianghong Liu and Haihong Ye and Yan Shen and Yan Li and Elizabeth J. Rao and Kazuo Fushimi and Xiaohong Zhou and Eileen H. Bigio and Marsel Mesulam and Qi Xu and Jane Y. Wu},
  journal={Protein & Cell},
  year={2011},
  volume={2},
  pages={477-486}
}
Mutations in the Fused in sarcoma/Translated in liposarcoma gene (FUS/TLS, FUS) have been identified among patients with amyotrophic lateral sclerosis (ALS). FUS protein aggregation is a major pathological hallmark of FUS proteinopathy, a group of neurodegenerative diseases characterized by FUS-immunoreactive inclusion bodies. We prepared transgenic Drosophila expressing either the wild type (Wt) or ALS-mutant human FUS protein (hFUS) using the UAS-Gal4 system. When expressing Wt, R524S or… CONTINUE READING

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