Expression of human CD4 in transgenic mice does not confer sensitivity to human immunodeficiency virus infection.

@article{Lors1992ExpressionOH,
  title={Expression of human CD4 in transgenic mice does not confer sensitivity to human immunodeficiency virus infection.},
  author={Patrick Lor{\`e}s and Virginie Boucher and Charles R Mackay and Marika Pla and Harald von Boehmer and J. Jami and Françoise Barr{\'e}-Sinoussi and J. C. Weill},
  journal={AIDS research and human retroviruses},
  year={1992},
  volume={8 12},
  pages={2063-71}
}
Transfection of the human CD4 molecule into mouse cells does not confer susceptibility to human immunodeficiency virus type 1 (HIV-1) infection. Expression of the human CD4 molecule in transgenic mice was seen to offer some new possibilities. However, transgenic mouse T cells expressing either the human CD4 receptor, or a hybrid human/mouse CD4 receptor… CONTINUE READING