Expression of hsp70 mRNA is induced in the brain of transgenic mice overexpressing human CuZn-superoxide dismutase following transient global cerebral ischemia.

@article{Kondo1996ExpressionOH,
  title={Expression of hsp70 mRNA is induced in the brain of transgenic mice overexpressing human CuZn-superoxide dismutase following transient global cerebral ischemia.},
  author={Toshihiko Kondo and Koji Murakami and Jari Honkaniemi and Frank R. Sharp and Charles J. Epstein and Pak Hoo Chan},
  journal={Brain research},
  year={1996},
  volume={737 1-2},
  pages={321-6}
}
We examined hsp70 mRNA expression in the brains of transgenic (Tg) mice overexpressing CuZn-superoxide dismutase and in wild-type (Wt) littermates after 3 min of bilateral common carotid artery occlusion. Significant induction of hsp70 mRNA occurred in the hippocampus, the cortex, and other brain regions of the Tg mice 4 h after ischemia compared to the Wt mice. However, there was no histological damage in the brains of Tg and Wt mice as assessed by both Cresyl violet staining and by TUNEL… CONTINUE READING
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