Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues.

@article{Waltregny2004ExpressionOH,
  title={Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues.},
  author={David Waltregny and Laurence de Leval and Wendy Gl{\'e}nisson and Siv Ly Tran and Brian J North and Akeila Bellahc{\'e}ne and Ulrich H. Weidle and Eric Verdin and Vincent Castronovo},
  journal={The American journal of pathology},
  year={2004},
  volume={165 2},
  pages={553-64}
}
Histone deacetylases (HDACs) were originally identified as nuclear enzymes involved in gene transcription regulation. Until recently, it was thought that their activity was restricted within the nucleus, with histones as unique substrates. The demonstration that specific HDACs deacetylate nonhistone proteins, such as p53 and alpha-tubulin, broadened the field of activity of these enzymes. HDAC8, a class I HDAC, is considered to be ubiquitously expressed, as suggested by results of Northern… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

Similar Papers

Loading similar papers…