Expression of histamine H1 receptors on cultured histiocytic lymphoma cells.

@article{Driver1989ExpressionOH,
  title={Expression of histamine H1 receptors on cultured histiocytic lymphoma cells.},
  author={Allison Driver and Cynthia A. Kukoly and Thomas H. Bennett},
  journal={Biochemical pharmacology},
  year={1989},
  volume={38 18},
  pages={3083-91}
}
Histamine H1 receptors were identified in U937 human histiocytic lymphoma cells using a radioligand binding technique with [3H]mepyramine. Reversible high-affinity binding with this ligand was obtained, and specificity of binding for selected H1 agonists and antagonists was demonstrated. Competition binding experiments with mepyramine and histamine yielded results consistent with single-site binding for mepyramine and two-site binding for histamine. Dissociation constants for the high- and low… CONTINUE READING

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