Expression of high affinity receptors for erythropoietin on human bone marrow cells and on the human erythroleukemic cell line, HEL.

@article{Fraser1988ExpressionOH,
  title={Expression of high affinity receptors for erythropoietin on human bone marrow cells and on the human erythroleukemic cell line, HEL.},
  author={John K. Fraser and Feng-ying Kimi Lin and Michael V Berridge},
  journal={Experimental hematology},
  year={1988},
  volume={16 10},
  pages={
          836-42
        }
}
The principal growth factor involved in the regulation of erythropoiesis, erythropoietin (Epo), is currently under clinical trial for the treatment of anemia. Despite the advanced state of these trials, little is known about the nature and distribution of the receptor for Epo on human hemopoietic cells or about the cellular mechanisms of signal transduction. In the present study 125I-labeled recombinant human Epo has been used to demonstrate expression of saturable, high affinity binding sites… CONTINUE READING

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