Expression of herpes simplex virus ICP47 and human cytomegalovirus US11 prevents recognition of transgene products by CD8(+) cytotoxic T lymphocytes.

Abstract

The in vivo persistence of gene-modified cells may be limited by the development of a host immune response to vector-encoded proteins. Herpesviruses evade cytotoxic T-lymphocyte (CTL) recognition by expressing genes which interfere selectively with presentation of viral antigens by class I major histocompatibility complex (MHC) molecules. Here, we studied… (More)

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@article{Berger2000ExpressionOH, title={Expression of herpes simplex virus ICP47 and human cytomegalovirus US11 prevents recognition of transgene products by CD8(+) cytotoxic T lymphocytes.}, author={Christel Berger and Sarah Xuereb and David C Johnson and Kathy S Watanabe and H P Kiem and Philip D. Greenberg and Stanley R Riddell}, journal={Journal of virology}, year={2000}, volume={74 10}, pages={4465-73} }