Expression of hepatoma‐derived growth factor in hepatocarcinogenesis

@article{Yoshida2003ExpressionOH,
  title={Expression of hepatoma‐derived growth factor in hepatocarcinogenesis},
  author={Kenya Yoshida and Hideji Nakamura and Yorihide Okuda and Hirayuki Enomoto and Yoshihiko Kishima and Hirokazu Uyama and Hiroaki Ito and Tsutomu Hirasawa and Shuichiro Inagaki and Ichiro Kawase},
  journal={Journal of Gastroenterology and Hepatology},
  year={2003},
  volume={18}
}
Background and Aim:  The present study investigated the expression of hepatoma‐derived growth factor (HDGF) in human hepatocellular carcinoma (HCC) and in the liver during hepatocarcinogenesis in two rodent models. 
Hepatoma‐derived growth factor is induced in liver regeneration
TLDR
It is shown that HDGF is highly expressed in parenchymal hepatocytes in the developing liver and promotes fetal hepatocyte proliferation and HDGF expression was related to liver regeneration.
Increased expression of hepatoma‐derived growth factor correlates with poor prognosis in human nasopharyngeal carcinoma
TLDR
Increased expression of hepatoma‐derived growth factor correlates with poor prognosis in human nasopharyngeal carcinoma.
Involvement of hepatoma-derived growth factor in the growth inhibition of hepatocellular carcinoma cells by vitamin K2
TLDR
Findings suggested that regulation of the HDGF gene expression is one of the crucial mechanisms of vitamin K2-induced cell growth suppression for HCC.
Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive Malignancies
Hepatoma-derived growth factor (HDGF) was identified in research seeking to find a novel growth factor for hepatoma cells. Subsequently, four HDGF-related proteins were identified, and these proteins
Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma
TLDR
The expression level of HDGF may be an independent prognostic factor for predicting the disease-free and overall survival in patients with various malignancies, including HCC.
Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis.
Hepatoma‐derived growth factor involved in the carcinogenesis of gastric epithelial cells through promotion of cell proliferation by Erk1/2 activation
TLDR
Analysis of the effect of HDGF transfection on the proliferation and on the changes of mitogen‐activated protein kinase (MAPK), Akt, and nuclear factor‐κB pathways in gastric cancer AGS cells suggests that HDGF is involved in the gastric carcinogenesis process and promotes proliferation and metastasis via Erk1/2 activation.
Hepatoma-Derived Growth Factor Is a Novel Prognostic Factor for Patients with Pancreatic Cancer
TLDR
Findings suggest that HDGF could be a novel prognostic factor for pancreatic ductal carcinoma.
Downregulation of hepatoma-derived growth factor activates the Bad-mediated apoptotic pathway in human cancer cells
TLDR
As HDGF knock-down not only suppresses the growth but also induces apoptosis in human cancer cells, HDGF may therefore serve as a survival factor for human cancers cells and a potential target for cancer therapy.
Hepatoma-derived growth factor and its role in keloid pathogenesis
TLDR
There was an increase in HDGF expression in the dermis of keloid compared with normal skin tissue and treatment with exogenous recombinant HDGF was found to increase the proliferation of KFs, activate the extracellular signal‐regulated kinase (ERK) pathway and up‐regulate the secretion of vascular endothelial growth factor (VEGF).
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