Expression of hepatoma‐derived growth factor in hepatocarcinogenesis

@article{Yoshida2003ExpressionOH,
  title={Expression of hepatoma‐derived growth factor in hepatocarcinogenesis},
  author={Kenya Yoshida and Hideji Nakamura and Yorihide Okuda and Hirayuki Enomoto and Yoshihiko Kishima and Hirokazu Uyama and Hiroaki Ito and Tsutomu Hirasawa and Shuichiro Inagaki and Ichiro Kawase},
  journal={Journal of Gastroenterology and Hepatology},
  year={2003},
  volume={18}
}
Background and Aim:  The present study investigated the expression of hepatoma‐derived growth factor (HDGF) in human hepatocellular carcinoma (HCC) and in the liver during hepatocarcinogenesis in two rodent models. 
View on Wiley
ncbi.nlm.nih.gov
45 Citations
Background Citations
19
Methods Citations
1

45 Citations

Citation Type

Citation Type

Hepatoma‐derived growth factor is induced in liver regeneration
TLDR
It is shown that HDGF is highly expressed in parenchymal hepatocytes in the developing liver and promotes fetal hepatocyte proliferation and HDGF expression was related to liver regeneration.
Increased expression of hepatoma‐derived growth factor correlates with poor prognosis in human nasopharyngeal carcinoma
TLDR
Increased expression of hepatoma‐derived growth factor correlates with poor prognosis in human nasopharyngeal carcinoma.
Involvement of hepatoma-derived growth factor in the growth inhibition of hepatocellular carcinoma cells by vitamin K2
TLDR
Findings suggested that regulation of the HDGF gene expression is one of the crucial mechanisms of vitamin K2-induced cell growth suppression for HCC.
Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive Malignancies
Hepatoma-derived growth factor (HDGF) was identified in research seeking to find a novel growth factor for hepatoma cells. Subsequently, four HDGF-related proteins were identified, and these proteins…
Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma
TLDR
The expression level of HDGF may be an independent prognostic factor for predicting the disease-free and overall survival in patients with various malignancies, including HCC.
Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis.
Hepatoma‐derived growth factor involved in the carcinogenesis of gastric epithelial cells through promotion of cell proliferation by Erk1/2 activation
TLDR
Analysis of the effect of HDGF transfection on the proliferation and on the changes of mitogen‐activated protein kinase (MAPK), Akt, and nuclear factor‐κB pathways in gastric cancer AGS cells suggests that HDGF is involved in the gastric carcinogenesis process and promotes proliferation and metastasis via Erk1/2 activation.
Hepatoma-Derived Growth Factor Is a Novel Prognostic Factor for Patients with Pancreatic Cancer
TLDR
Findings suggest that HDGF could be a novel prognostic factor for pancreatic ductal carcinoma.
Downregulation of hepatoma-derived growth factor activates the Bad-mediated apoptotic pathway in human cancer cells
TLDR
As HDGF knock-down not only suppresses the growth but also induces apoptosis in human cancer cells, HDGF may therefore serve as a survival factor for human cancers cells and a potential target for cancer therapy.
Hepatoma-derived growth factor and its role in keloid pathogenesis
TLDR
There was an increase in HDGF expression in the dermis of keloid compared with normal skin tissue and treatment with exogenous recombinant HDGF was found to increase the proliferation of KFs, activate the extracellular signal‐regulated kinase (ERK) pathway and up‐regulate the secretion of vascular endothelial growth factor (VEGF).
...
...

References

SHOWING 1-10 OF 50 REFERENCES
Expression of heparin‐binding epidermal growth factor‐like growth factor in the hepatocytes of fibrotic rat liver during hepatocarcinogenesis
TLDR
The expression of the growth factor in the hepatocytes of fibrotic liver during hepatocarcinogenesis was investigated and it was found that hepatotrophic factor is expressed in non‐parenchymal liver cells but not in hepatocytes in regenerating rat liver after partial hepatectomy.
Hepatoma‐derived growth factor is highly expressed in developing liver and promotes fetal hepatocyte proliferation
TLDR
Hepatoma‐derived growth factor helps regulate the hepatocyte proliferation in liver development and the inhibitory effect of HDGF antisense virus was reversed by exogenous HDGF.
Hepatoma-derived growth factor is highly expressed in developing liver and promotes fetal hepatocyte proliferation.
TLDR
Hepatoma-derived growth factor helps regulate the hepatocyte proliferation in liver development and the inhibitory effect of HDGF antisense virus was reversed by exogenous HDGF.
Expression of heparin-binding epidermal growth factor in human hepatocellular carcinoma.
Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis.
TLDR
Levels of HGF and c-met mRNA evaluated in rat livers during development of 2-acetylaminofluorene (2-AAF)-selected preneoplastic nodules and carcinomas suggest they are directly involved in a paracrine growth pathway controlling proliferation in normal hepatocytes and oval cells, but not in preneopastic and neoplastic cells.
Antisense oligonucleotides of hepatoma-derived growth factor (HDGF) suppress the proliferation of hepatoma cells.
TLDR
Hepatoma-derived growth factor is one of important autocrine, and/or intracrine factors for hepatoma cells, and that hepatoma- derived growth factor anti-sense oligonucleotides may be useful for human hepatocellular carcinoma as an anti-cancer agent is suggested.
Liver regeneration and hepatocarcinogenesis in transforming growth factor‐α‐targeted mice
TLDR
It is reported here that although a 70% hepatectomy produced a significant increase in hepatic TGFα protein levels in wild‐type mice, liver regeneration nevertheless proceeded normally in the absence of the growth factor.
Mouse liver tumorigenesis: models, mechanisms, and relevance to human disease.
  • N. Fausto
  • Biology, Medicine
    Seminars in liver disease
  • 1999
TLDR
Work with transgenic and knockout mice indicate that regardless of the initiating cause, constitutive hepatocyte proliferation accompanied by genomic damage are essential factors for liver tumor development.
High expression of heparin‐binding EGF‐like growth factor in rat hepatocarcinogenesis
TLDR
The results suggest that HB‐EGF is associated with the early progression steps of hepatoma, and this expression was investigated during hepatocarcinogenesis in LEC rats, which spontaneously develop hepatitis and hepatoma.
Expression of the hepatocyte growth factor-like protein gene in human hepatocellular carcinoma and interleukin-6-induced increased expression in hepatoma cells.
...
...