Expression of hepatocyte growth factor activator and hepatocyte growth factor activator inhibitor type 1 in human hepatocellular carcinoma.

@article{Nagata2001ExpressionOH,
  title={Expression of hepatocyte growth factor activator and hepatocyte growth factor activator inhibitor type 1 in human hepatocellular carcinoma.},
  author={Kazuhiro Nagata and Shuichi Hirono and Akio Ido and Hideo Kataoka and Akihiro Moriuchi and Takeshi Shimomura and Takeshi Hori and Katsuhiro Hayashi and Masashi Koono and Naomi Kitamura and Hirohito Tsubouchi},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={289 1},
  pages={205-11}
}
Hepatocyte growth factor activator inhibitor type 1 (HAI-1), a Kunitz-type serine protease inhibitor for hepatocyte growth factor activator (HGFA), is responsible for proteolytic activation of hepatocyte growth factor. We examined the expression of HGFA and HAI-1 in liver tissues of chronic liver diseases including hepatocellular carcinoma (HCC). HGFA expression was detected not only in the liver tissues of chronic hepatitis and cirrhosis and in the nontumorous liver tissues surrounding HCC… CONTINUE READING
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