Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway.

@article{Heim1999ExpressionOH,
  title={Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway.},
  author={Markus H Heim and Darius Moradpour and H. E. Blum},
  journal={Journal of virology},
  year={1999},
  volume={73 10},
  pages={8469-75}
}
Hepatitis C virus (HCV) infection is a leading cause of liver disease worldwide. Alpha interferon (IFN-alpha) therapy of chronic hepatitis C leads to a sustained response in 10 to 20% of patients only. The mechanisms of viral persistence and the pathogenesis of hepatitis C are poorly understood. We established continuous human cell lines, allowing the tightly regulated expression of the entire HCV open reading frame under the control of a tetracycline-responsive promoter. Using this in vitro… CONTINUE READING
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