Expression of heparanase in vascular cells and astrocytes of the mouse brain after focal cerebral ischemia.

@article{Li2012ExpressionOH,
  title={Expression of heparanase in vascular cells and astrocytes of the mouse brain after focal cerebral ischemia.},
  author={Jimei Li and Jin-Ping Li and Xiao Zhang and Zhongyang Lu and Shan Ping Yu and Ling Wei},
  journal={Brain research},
  year={2012},
  volume={1433},
  pages={137-44}
}
Heparanase is a heparan sulfate degrading endoglycosidase. Previous work has demonstrated that heparanase plays important roles in various biological processes including angiogenesis, wound healing and metastasis. However, the role of heparanase in the post-ischemic brain is not well defined. Transient focal cerebral ischemia in adult mice was induced by ligations of the right middle cerebral artery (MCA) and both common carotid arteries (CCAs). All mice were subjected to bromodeoxyuridine… CONTINUE READING

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