Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation.

@article{Vlodavsky1992ExpressionOH,
  title={Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation.},
  author={Israel Vlodavsky and Amiram Eldor and Adriana Haimovitz-Friedman and Yaacov Matzner and Riva Ishai-Michaeli and Ofer Lider and Yaakov Naparstek and Isabelle R. Cohen and Zvi Fuks},
  journal={Invasion & metastasis},
  year={1992},
  volume={12 2},
  pages={112-27}
}
Interaction of T and B lymphocytes, platelets, granulocytes, macrophages and mast cells with the subendothelial extracellular matrix (ECM) is associated with degradation of heparan sulfate (HS) by a specific endoglycosidase (heparanase) activity. The enzyme is released from intracellular compartments (i.e., lysosomes, specific granules) in response to various activation signals (i.e., thrombin, calcium ionophore, immune complexes, antigens, mitogens), suggesting its regulated involvement in… CONTINUE READING
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