Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules.

@article{Lim2005ExpressionOH,
  title={Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules.},
  author={Seung-Oe Lim and Sung-Gyoo Park and Jun-hi Yoo and Young-Min Park and Hie-Joon Kim and Kee-Taek Jang and Jae Won Cho and Byung Chul Yoo and Guhung Jung and C. Park},
  journal={World journal of gastroenterology},
  year={2005},
  volume={11 14},
  pages={
          2072-9
        }
}
AIM Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)-related HCC. METHODS Thirty-eight HCC and… Expand
Upregulation of Heat Shock Proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in Tumour Tissues Is Associated with Poor Outcomes from HBV-Related Early-Stage Hepatocellular Carcinoma
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The expression of most HSPs was higher in tumour tissues than in non-tumour tissues, whereas high levels of HSPA4, HSPA5 and HSPA6 might be associated with earlier recurrence of HCC. Expand
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Dynamic expression of rat heat shock protein gp96 and its gene during development of hepatocellular carcinoma.
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  • 2007
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HSP gp96 is involved in HCC development and its overexpression may be a useful marker for early diagnosis. Expand
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TLDR
HSP70 is a key regulator involved in the proliferation, migration and invasion of HCC, and it may be used as a potential therapeutic target for HCC. Expand
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