Expression of heat-shock protein Hsp60 correlated with the apoptotic index and patient prognosis in human oesophageal squamous cell carcinoma.

@article{Faried2004ExpressionOH,
  title={Expression of heat-shock protein Hsp60 correlated with the apoptotic index and patient prognosis in human oesophageal squamous cell carcinoma.},
  author={Ahmad Faried and Makoto Sohda and Masanobu Nakajima and Tatsuya Miyazaki and Hoichi Kato and Hiroyuki Kuwano},
  journal={European journal of cancer},
  year={2004},
  volume={40 18},
  pages={2804-11}
}
Cellular stress response and apoptosis are two highly conserved mechanisms for maintaining homeostasis. Hsp60 and Hsp90 have been shown to play pro- and anti-apoptotic roles, respectively. Our present study examined whether there is a correlation between the expression of Hsp60 and Hsp90, clinical parameters, the apoptotic index (AI), and the prognosis of patients with oesophageal squamous cell carcinoma (ESCC). We immunohistochemically stained cells for Hsp60, Hsp90, and single-stranded DNA… CONTINUE READING