Expression of heat shock protein 47, transforming growth factor-beta 1, and connective tissue growth factor in liver tissue of patients with Schistosoma japonicum-induced hepatic fibrosis.

@article{Li2015ExpressionOH,
  title={Expression of heat shock protein 47, transforming growth factor-beta 1, and connective tissue growth factor in liver tissue of patients with Schistosoma japonicum-induced hepatic fibrosis.},
  author={Lan Li and Ting Wu and Jiaquan Huang and Ke Ma and Lei Xu and Hongwu Wang and Xiangxue Fan and Ran Tao and Guo Ai and Xiaoyang Wan},
  journal={Parasitology},
  year={2015},
  volume={142 2},
  pages={341-51}
}
SUMMARY To detect the expression of pro-fibrotic molecules, such as heat shock protein 47 (Hsp47), transforming growth factor-beta 1 (TGF-β1) and connective tissue growth factor (CTGF) in liver specimens, and analyse their correlations with the progression of schistosomal hepatic fibrosis, liver biopsy was performed in 42 chronic schistosomiasis (CS) patients, 16 chronic hepatitis B (CHB) patients and five healthy individuals (HI). Immunohistochemistry (IHC) analyses displayed that the… CONTINUE READING
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