Corpus ID: 16683

Expression of hHR21sp gene by peripheral blood and hematopoietic cells of normal subjects and Fanconi anemia patients.

@article{Deng2001ExpressionOH,
  title={Expression of hHR21sp gene by peripheral blood and hematopoietic cells of normal subjects and Fanconi anemia patients.},
  author={Y. Deng and S. Li and X. Li and T. Magali},
  journal={Chinese medical journal},
  year={2001},
  volume={114 12},
  pages={
          1295-9
        }
}
OBJECTIVE The radiation sensitive gene rad 21 of Schizosaccharomyces pombe is involved in the repair of double-stranded breaks in DNA and is essential for mitotic growth. The hHR21sp gene is its human homologue. In an attempt to investigate the role of hHR21sp in DNA repair, we studied the effects of UV and gamma-ray irradiation on hHR21sp gene expression in normal human peripheral blood cells, and non-iradiated peripheral and bone marrow cells from Fanconi anemia (FA) patients who have shown… Expand
Long noncoding RNA CDKN2B‐AS1 interacts with transcription factor BCL11A to regulate progression of cerebral infarction through mediating MAP4K1 transcription
  • Junjie Lei, Huiqing Li, +5 authors L. Zhang
  • Medicine, Biology
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2019
TLDR
Evidence is provided that CDKN2B‐AS1 silencing could increase MAP4K1 expression to inhibit the CD4+CD25+ Treg‐cell proliferation by reducing enrichment of transcription factor BCL11A, thereby protecting against cerebral infarction progression, highlighting a promising therapeutic strategy for treating cerebral infARction. Expand