Expression of growth factors and growth factor receptors in soft tissue tumors. Implications for the autocrine hypothesis.


According to the autocrine hypothesis of cell growth, tumors, in contrast to normal tissue, might simultaneously express both a growth factor and its receptor, resulting in autoregulation and autostimulation of growth. In a related hypothesis, expression of either a growth factor or receptor might allow a tumor to escape exogenous controls on growth, and… (More)


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