Expression of granzyme A and B proteins by cytotoxic lymphocytes involved in acute renal allograft rejection.

@article{Kummer1995ExpressionOG,
  title={Expression of granzyme A and B proteins by cytotoxic lymphocytes involved in acute renal allograft rejection.},
  author={Jean Alain Kummer and Peter C. Wever and Andre Kamp and Ineke J M Ten Berge and Cornelis Erik Hack and Jan J. Weening},
  journal={Kidney international},
  year={1995},
  volume={47 1},
  pages={
          70-7
        }
}
Granzymes A and B are serine-proteinases stored in the granules of activated cytotoxic T-lymphocytes and natural killer (NK) cells. Expression of granzymes in tissues can be used as an activation marker for cytotoxic cells. Using mAbs specific for human granzyme A or B in immunohistochemical staining techniques we investigated expression of granzyme A and B by lymphocytes infiltrating acutely rejected renal allografts. Twelve core needle biopsies were taken from ten different patients during an… CONTINUE READING

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