Expression of gp91phox and p22phox, catalytic subunits of NADPH oxidase, on microglia in Nasu-Hakola disease brains.

@article{Satoh2016ExpressionOG,
  title={Expression of gp91phox and p22phox, catalytic subunits of NADPH oxidase, on microglia in Nasu-Hakola disease brains.},
  author={Jun-ichi Satoh and Yoshihiro Kino and Motoaki Yanaizu and Youhei Tosaki and Kenji Sakai and Tusyoshi Ishida and Yuko Saito},
  journal={Intractable & rare diseases research},
  year={2016},
  volume={5 4},
  pages={
          275-279
        }
}
The superoxide-producing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex of phagocytes (phox) plays a key role in production of reactive oxygen species (ROS) by microglia. The catalytic subunits of the NADPH oxidase are composed of p22phox and gp91phox. Nasu-Hakola disease (NHD) is a rare autosomal recessive disorder caused by a loss-of-function mutation of either TYROBP (DAP12) or TREM2. Pathologically, the brains of NHD patients exhibit extensive demyelination designated… CONTINUE READING

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