Expression of gp100 and CDK2 in melanoma cells is not co-regulated by a shared promoter region.

@article{Stennett2004ExpressionOG,
  title={Expression of gp100 and CDK2 in melanoma cells is not co-regulated by a shared promoter region.},
  author={Lawrence S Stennett and Adam I. Riker and Tara M. Kroll and J R Chamberlin and Toru Miki and Brian J. Nickoloff and I. Caroline Le Poole},
  journal={Pigment cell research},
  year={2004},
  volume={17 5},
  pages={525-32}
}
Expression of the pigmentation-associated gene PMel17 is regulated by a 1 kB promoter region shared between the PMel17 and CDK2 genes. The encoded melanosomal glycoprotein gp100 and the cell cycle regulatory protein CDK2 are transcribed in opposite directions. Luciferase reporter constructs were generated for subregions of the promoter containing 0, 1, 2 or… CONTINUE READING