Expression of glypican 3 in ovarian and extragonadal germ cell tumors.

  title={Expression of glypican 3 in ovarian and extragonadal germ cell tumors.},
  author={Debra L. Zynger and Michael J Everton and Nikolay D Dimov and Pauline M. Chou and Ximing J. Yang},
  journal={American journal of clinical pathology},
  volume={130 2},
Germ cell tumors (GCTs), rare malignancies that occur in a wide range of locations and display variable histologic patterns, may pose diagnostic challenges. Glypican 3 (GPC3), a membrane-bound heparan sulfate proteoglycan, has been shown to be a novel diagnostic marker in testicular GCT. However, GPC3 expression in ovarian and extragonadal GCT has not been reported. We evaluated GPC3 immunoreactivity in GCTs from 63 patients (57 children and 6 adults), including 14 ovarian and 20 extragonadal… CONTINUE READING


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