Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo.

@article{Peltoniemi2004ExpressionOG,
  title={Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo.},
  author={Mirva Peltoniemi and Riitta L Kaarteenaho-Wiik and Marjaana S{\"a}ily and Raija T. Sormunen and Paavo K P{\"a}{\"a}kk{\"o} and Arne Holmgren and Ylermi M Soini and Vuokko L. Kinnula},
  journal={Human pathology},
  year={2004},
  volume={35 8},
  pages={1000-7}
}
Glutaredoxins (Grx) are thiol-disulfide oxidoreductases with antioxidant capacity and catalytic functions closely associated with glutathione, an antioxidant abundantly present in human lung. The present study investigated the expression of both human glutaredoxins in cultured human lung cells and lung homogenates by reverse-transcription polymerase chain reaction and Western blotting. Immunohistochemical studies were conducted with 38 human lung specimens, including healthy lung, parenchymal… CONTINUE READING

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