Expression of glutaredoxin in human coronary arteries: its potential role in antioxidant protection against atherosclerosis.

@article{Okuda2001ExpressionOG,
  title={Expression of glutaredoxin in human coronary arteries: its potential role in antioxidant protection against atherosclerosis.},
  author={Masato Okuda and Nobutaka Inoue and Hiroshi Azumi and Tadashi Seno and Yoshihiko Sumi and Hirata Ki and Seinosuke Kawashima and Yoshitake Hayashi and Hiroshi Itoh and Junji Yodoi and Masaki Yokoyama},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2001},
  volume={21 9},
  pages={1483-7}
}
Oxidative stress is considered an important factor in atherogenesis. Mammalian cells have a complex network of antioxidants such as catalase, superoxide dismutase, and glutathione peroxidase. However, the mechanisms that regulate the cellular redox state in the vessel wall remain unclear. Recent study has shown that thioredoxin, a thiol-disulfide oxidoreductase, is expressed in atherosclerotic plaques of human carotid arteries. In this study, we investigated the localization and expressional… CONTINUE READING

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