Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma.

@article{Zhuang2009ExpressionOG,
  title={Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma.},
  author={Liquing Zhuang and Richard A Scolyer and Cheok Soon Lee and S. W. McCarthy and Wendy A. Cooper and Xu Dong Zhang and John F Thompson and Peter Hersey},
  journal={Histopathology},
  year={2009},
  volume={54 4},
  pages={462-70}
}
AIMS Glucose-regulated protein 78 (GRP78) is a protein translated in response to endoplasmic reticulum (ER) stress that has been implicated in the pathogenesis and resistance to therapy of a variety of cancers. The aim of this study was to investigate its expression and role in the development and progression of human melanoma. METHODS AND RESULTS The immunohistochemical expression of GRP78 in naevi, primary melanoma and melanoma metastases from 171 patients was correlated with… CONTINUE READING
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