Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues.

@article{Pujols2002ExpressionOG,
  title={Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues.},
  author={Laura Pujols and Joaquim Mullol and Jordi Roca-Ferrer and A. Torrego and Antoni Xaubet and John Anthony Cidlowski and C{\'e}sar Picado},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={283 4},
  pages={C1324-31}
}
Alternative splicing of the human glucocorticoid receptor (GR) primary transcript generates two protein isoforms: GR-alpha and GR-beta. We investigated the expression of both GR isoforms in healthy human cells and tissues. GR-alpha mRNA abundance (x10(6) cDNA copies/microg total RNA) was as follows: brain (3.83 +/- 0.80) > skeletal muscle > macrophages > lung > kidney > liver > heart > eosinophils > peripheral blood mononuclear cells (PBMCs) > nasal mucosa > neutrophils > colon (0.33 +/- 0.04… CONTINUE READING
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