Expression of glucocorticoid-induced tumor necrosis factor receptor ligand in rat graft after liver transplantation.

Abstract

BACKGROUND Costimulation between the glucocorticoid-induced tumor necrosis factor receptor and its ligand (GITRL) breaks immunologic tolerance induced by regulatory T cells. The purpose of this research was to examine the involvement of GITRL during rat liver transplantation, the survival of which depends on interactions between regulatory T cells and Kupffer cells (KCs). METHODS Recipients were divided into 2 groups: The allograft group underwent orthotopic liver transplantation from male Lewis to Brown Norway (BN) rats and the isograft group, BN-to-BN liver transplantation. We evaluated 2-week survival rates, histologic changes, as well as serum and supernatant levels of tumor necrosis factor-α (TNF-α); GITRL, and TNF-α expressions in the graft, and GITRL expression by graft-derived KCs. RESULTS TNF-α levels were increased in plasma and in the supernates of KCs during allograft transplantation compared with isograft liver transplantation (P <.05). The expressions of TNF-α and GITRL in liver grafts were increased during acute rejection. Furthermore, the expression of GITRL on KCs derived from allografts was increased compared with isografts (P < .05). CONCLUSION GITRL expression on KCs may mediate acute rejection in liver transplantation.

DOI: 10.1016/j.transproceed.2011.03.054

Statistics

05001000201220132014201520162017
Citations per Year

125 Citations

Semantic Scholar estimates that this publication has 125 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Wei2011ExpressionOG, title={Expression of glucocorticoid-induced tumor necrosis factor receptor ligand in rat graft after liver transplantation.}, author={Shu Wei and Ji-cheng Li and Zhaorui Lian and Yeting Chen and Z Liu and Hong You and Jian Ping Gong}, journal={Transplantation proceedings}, year={2011}, volume={43 5}, pages={1971-5} }