Expression of genes of potential importance in the response to chemotherapy and DNA repair in patients with ovarian cancer.

@article{Codegoni1997ExpressionOG,
  title={Expression of genes of potential importance in the response to chemotherapy and DNA repair in patients with ovarian cancer.},
  author={Annamaria Codegoni and Massimo Broggini and M R Pitelli and Marcos Pantarotto and Valter Torri and Costantino Mangioni and Maurizio D'Incalci},
  journal={Gynecologic oncology},
  year={1997},
  volume={65 1},
  pages={
          130-7
        }
}
The expression of different genes potentially involved in DNA repair and in cell responses to chemotherapy was evaluated in 33 previously untreated ovarian cancer patients. In biopsies of the same patients the expression of repair genes O6-methylguanine DNA methyltransferase (MGMT), 3-methyladenine DNA glycosylase (MAG), ERCC1, MDR-1, DNA topoisomerase I, DNA topoisomerase IIalpha, and glutathione S-transferase-pi (GST-pi) was assessed by Northern blot analysis. No direct statistical… CONTINUE READING

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