Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterning.

@article{FrancisWest1995ExpressionOG,
  title={Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterning.},
  author={Philippa H Francis-West and Kerstin Robertson and Dr. D. A. Ede and Concepci{\'o}n Alonso Rodr{\'i}guez and Juan Carlos Izpis{\'u}a-Belmonte and Brittany Houston and David W. Burt and Clare Gribbin and Paul M. Brickell and Cheryll Tickle},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={1995},
  volume={203 2},
  pages={
          187-97
        }
}
The chicken mutant talpid3 (ta3) has polydactylous limbs with up to 7-8 morphologically similar digits. This lack of antero-posterior polarity in digit pattern is correlated with symmetrical expression of genes of the HoxD complex. We determined the distribution of polarizing activity in limb buds of the chick mutant ta3 by assessing the ability of mesenchyme from various positions along the antero-posterior axis to induce digit duplications when grafted anteriorly into a normal limb. Cells… CONTINUE READING
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