Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins

@article{Martn2004ExpressionOG,
  title={Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins},
  author={Juan Francisco Mart{\'i}n and Santiago Guti{\'e}rrez and Francisco J Fern{\'a}ndez and Javier Velasco and Francisco Fierro and Ana T Marcos and Katarina Kosalkov{\'a}},
  journal={Antonie van Leeuwenhoek},
  year={2004},
  volume={65},
  pages={227-243}
}
The genespcbAB,pcbC andpenDE encoding the enzymes (α-aminoadipyl-cysteinyl-valine synthetase, isopenicillin N synthase and isopenicillin N acyltransferase, respectively) involved in the biosynthesis of penicillin have been cloned fromPenicillium chrysogenum andAspergillus nidulans. They are clustered in chromosome I (10.4 Mb) ofP. chrysogenum, in chromosome II ofPenicillium notatum (9.6 Mb) and in chromosome VI (3.0 Mb) ofA. nidulans. Each gene is expressed as a single transcript from separate… Expand
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