Expression of gangliosides, GD1a, and sialyl paragloboside is regulated by NF‐κB‐dependent transcriptional control of α2,3‐sialyltransferase I, II, and VI in human castration‐resistant prostate cancer cells

@article{Hatano2011ExpressionOG,
  title={Expression of gangliosides, GD1a, and sialyl paragloboside is regulated by NF‐$\kappa$B‐dependent transcriptional control of $\alpha$2,3‐sialyltransferase I, II, and VI in human castration‐resistant prostate cancer cells},
  author={Koji Hatano and Yasuhide Miyamoto and Norio Nonomura and Yasufumi Kaneda},
  journal={International Journal of Cancer},
  year={2011},
  volume={129}
}
Gangliosides are sialic acid–containing glycosphingolipids that are associated with tumor malignancy and progression. Among the enzymes required for the production of gangliosides, sialyltransferases have received much attention in terms of their relationship with cancer. In our previous report, ganglioside GD1a and sialyl paragloboside (SPG), a neolacto‐series ganglioside, were much more abundant in PC3 and DU145 cells, castration‐resistant prostate cancer cells, as compared with hormone… 
Androgen-Regulated Transcriptional Control of Sialyltransferases in Prostate Cancer Cells
TLDR
It is demonstrated that GD1a was produced in abundance in cancerous tissue samples from human patients with hormone-sensitive prostate cancers as well as castration-resistant prostate cancers, and this is the first report indicating that the expression of a sialyltransferase is transcriptionally regulated by androgen-dependent demethylation of the CpG sites in its gene promoter.
B4GALNT1 induces angiogenesis, anchorage independence growth and motility, and promotes tumorigenesis in melanoma by induction of ganglioside GM2/GD2
TLDR
It is concluded that B4GALNT1, and consequently GM2/GD2, enhanced tumorigenesis via induction of angiogenesis, AIG, and cell motility, which may lead to development of novel therapy for refractory melanoma.
Control of expression of glycosyltransferases involved in O-linked glycosylation in breast cancer
TLDR
Investigation of the control by PGE2/COX-2 of ST3Gal-I and C2GnT1 expression in breast carcinomas found a significant correlation between the two enzymes, suggesting the intriguing possibility that some of the malignant characteristics associated with COx-2 may be via the influence that COX- 2 exerts on the glycosylation of tumour cells.
Biological Roles of Aberrantly Expressed Glycosphingolipids and Related Enzymes in Human Cancer Development and Progression
TLDR
Recent studies on aberrant expression and distribution of GSLs in common human cancers (breast, lung, colorectal, melanoma, prostate, ovarian, leukemia, renal, bladder, gastric, and gastric) are summarized.
Gangliosides in Cancer Cell Signaling.
Glycosylation Changes in Prostate Cancer Progression
TLDR
The clinical utility and potential impact of exploiting glycans as both biomarkers and therapeutic targets to improve the ability to diagnose clinically relevant tumors as well as expand treatment options for patients with advanced disease are emphasized.
Bisecting-GlcNAc on Asn388 is characteristic to ERC/mesothelin expressed on epithelioid mesothelioma cells
TLDR
Results suggest that this glycoproteome could serve as a potential target for the generation of a highly selective and safe therapeutic antibody for epithelioid mesothelioma.
13‐Cis retinoic acid can enhance the antitumor activity of non‐replicating Sendai virus particle against neuroblastoma
TLDR
HVJ‐E is a promising therapeutic modality for neuroblastoma and 13cRA can be used as an adjuvant to HVJ •E, which could achieve partial eradication of the xenograft and lead to an improved prognosis.
A Novel Method for the Production of Glycosphingolipids
TLDR
Four ganglioside analogs were synthesized by the saccharide-primer method using MDCK cells and β-lactoside primer with different aglycons and the yield of SPG was much higher than that obtained by former methods.
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