Expression of functional trk protooncogene in human monocytes.

  title={Expression of functional trk protooncogene in human monocytes.},
  author={Peter Ehrhard and U M Ganter and A Stalder and J{\"u}rgen Bauer and Uwe Otten},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 12},
There is increasing evidence that neurotrophins, including nerve growth factor (NGF), exert specific effects on cells of the immune system in addition to their neurotrophic actions. This report shows that human monocytes express the trk protooncogene, encoding the signal-transducing receptor unit for NGF. This receptor is functional, since interaction of NGF with monocytes triggered a respiratory burst, the major component of monocyte cytotoxic activity. During in vitro differentiation of human… CONTINUE READING
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